Pattie Mathieu, Ph.D.

Biography

Dr. Pattie Mathieu joined Marian University in August 2023 as an Assistant Professor of Biomedical Engineering. Her research interests include cardiovascular mechanobiology and metabolism. Her Ph.D. work at Trinity College Dublin focused on how collagen structure and tensile strain affect vascular stem cell and vascular smooth muscle cell phenotype and proliferation. In her postdoctoral work at the University of Maryland she investigated how glutamine metabolism influences vascular smooth muscle cell glucose metabolism and studying how cell alignment can change vascular smooth muscle cell metabolism. Her current research interests focus on applying her vascular mechanobiology knowledge to vascular calcification and the related cardiovascular diseases. Additionally, Dr. Mathieu teaches multiple classes in engineering and physics.

Education

• Ph.D., Biomedical Engineering, Trinity College Dublin
  
• M.S., Biomedical Engineering, NC State University and University of North Carolina Joint Department of Biomedical Engineering
  
• B.S., Biomedical Engineering, University of Virginia

Interests and Expertise

Cardiovascular disease, mechanobiology, tissue Engineering, vascular stem cells, vascular smooth muscle cells, vascular calcification, glutamine metabolism, glucose metabolism, decellularization, tensile strain bioreactors, micropatterns

Selected Papers

• Mathieu, P.S., Fitzpatrick, E., Di Luca, M., Cahill, P.A., Lally, C. (2022) Native extracellular matrix orientation determines multipotent vascular stem cell proliferation in response to cyclic uniaxial tensile strain and simulated stent indentation. Biochemistry and Biophysics Reports. 29:101183
  
• Mathieu, P.S., Fitzpatrick, E., Di Luca, M., Cahill, P.A., Lally, C. (2019) Resident Multipotent Vascular Stem Cells Exhibit Strain Amplitude Dependent Strain Avoidance Similar to that of Vascular Smooth Muscle Cells. Biochemical and Biophysical Research Communications. 521 (3): 762-768
  
• Mathieu, P.S., Bodle, J.C., Loboa, E.G. (2014) Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix. Journal of Biomechanics. 47(9): 2211-2217
  
• Mathieu, P.S., Loboa, E.G. (2012) Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic and chondrogenic pathways. Tissue Engineering Part B. 18(6): 436-444