Kyung S. Kang, Ph.D.

Biography

Dr. Kang has long been interested in integrating mechanical engineering technologies into bio-applications. His Ph.D. work at Pohang University of Science and Engineering (POSTECH) in Pohang, South Korea, was in design, characterization, and evaluation of an in vitro cell stimulation device with biophysical stimuli for tissue engineering and regenerative medicine. He also utilized additive manufacturing techniques to provide a three-dimensional environment for cells during culture. He optimized the parameters of electromagnetic field and ultrasound stimuli to specifically enhance cellular functions and evaluated their combined effects with a biomimetic stimulus on bone regeneration. He further pursued how mechanical stimuli affect cellular metabolism and behavior (i.e., mechanotransduction) as a post-doctoral fellow at Indiana University School of Medicine. He utilized genetically modified mice to observe which cellular mechanisms are associated with external mechanical loading to bones, especially via the Wnt signaling pathway. Additionally, he has worked to develop a reliable osteocyte in vitro culture model using 3D-shaped collagen and mechanical stimuli. He has served at Marian University since 2022.

Education

• Ph.D., Mechanical Engineering, Pohang University of Science and Technology
  

Research Interests and Expertise

Tissue engineering, Regenerative medicine, 3D printing, 3D scanning, Bone biology, Biomedical devices, kinematic mechanism, robotics, engineering entrepreneurship, engineering education, STEM education.

Selected Papers

• H Yi, Y H Jeong, Y Kim, Y Choi, H E Moon, S H Park, K S Kang, M Bae, J Jang, H Youn, S H Paek, D Cho. “A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy.” Nature Biomedical Engineering, Mar 2019. 
• K S Kang, J M Hong, D J Horan, K Lim, A Bruzzaniti, S Hahn, M L Warman, A G Robling. “Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism.” Bone, 25(120):166 – 175, Mar 2019.  
• K S Kang, J M Hong, A G Robling. “Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.” Bone 88:138-145, Jul 2016. 
• K S Kang, J M Hong, Y Seol, W Yong, J Rhie, Y H Jeong, D Cho. “Combined effect of three types of biophysical stimuli for bone regeneration.” Tissue Engineering Part A 20(11-12), 1767-1777, May 2014. 
• J M Hong*, K S Kang*, H Yi, S Kim, D Cho. “Electromagnetically controllable osteoclast activity.” Bone. 62:99-107, May 2014. (* These authors contributed equally to this study) 
• K S Kang*, S Lee*, J M Hong, J W Lee, H Y Cho, J H Son, S H Paek, D Cho. “Hybrid scaffold composed of hydrogel/3D-framework and its application as a dopamine delivery system.” Journal of Controlled Release 175:10-16, Feb 2014. (* These authors contributed equally to this study) 
• K S Kang*, Y H Jeong*, J M Hong, W Yong, J Rhie, D Cho. “Flexure-based device for cyclic-mediated osteogenic differentiation.” ASME-Journal of Biomechanical Engineering 135(11), 114501, Nov 2013. (* These authors contributed equally to this study)