Primary research goal: Study intracellular signaling pathways with a focus on roles of protein kinases/phosphatases on smooth muscle contractility in health and disease.
Changlong An, Bhupal P Bhetwal, Kenton M Sanders, Avril V Somlyo, and Brian A Perrino. Role of telokin in regulating murine gastric fundus smooth muscle tension. PLoS One. 2015 Aug 10;10(8).
Shuiqiao Yuan, Clifford J Stratton, Jianqiang Bao, Huili Zheng, Bhupal P Bhetwal, Ryuzo Yanagimachi, and Wei Yan. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Proceedings of National Academy of Sciences, USA. 2015 Feb 3; 112(5): E430–E439.
Bhupal P Bhetwal, Changlong An, Salah A Baker, Kristin L Lyon, and Brian A Perrino. Impaired contractile responses and altered expression and phosphorylation of Ca2+ sensitization proteins in gastric antrum smooth muscles from ob/ob mice. Journal of Muscle Research and Cell Motility. 2013 May; 34(2):137-49.
Bhupal P Bhetwal, Kenton M Sanders, Changlong An, Danielle M. Trappenese, Robert S Moreland, and Brian A Perrino. Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus. Journal of Physiology, 2013 Jun 15; 591 (Pt 12):2971-86. Editor's choice and commented.
Bhupal P Bhetwal, Changlong An, Steve A Fisher, and Brian A Perrino. Regulation of basal LC20 phosphorylation by MYPT1 and CPI-17 in murine gastric antrum, gastric fundus, and proximal colon smooth muscles. Neurogastroenterology and Motility (Oct, 2011) 23, e425–e436.