During the early career of Dr. Klabunde (1970-1985), his research focused on metabolism-linked regulation of blood flow in skeletal muscle, particularly on the role of oxygen and adenosine. Over the next 22 years, he studied the mechanisms of action of various cardiovascular drugs in animal models of heart failure and septic shock, the efficacy of different types of thrombolytic agents, and the mechanisms by which nitric oxide regulates cardiac contractile function and microcirculatory function. Most of the cardiac work was performed using isolated, Langendorff-perfused rat and mouse hearts. The last few years of his research focused on how diabetes and obesity affect nitric oxide, endothelin and adrenergic control of the coronary circulation.
Dr. Klabunde ended his laboratory research a few years ago to concentrate on other scholarly activities, including writing textbooks, managing the content of teaching websites, and serving as a consultant for cardiovascular research and teaching.
1. Klabunde, RE. Normal and Abnormal Blood Pressure (Physiology, Pathophysiology and Treatment). Amazon Kindle book, 2013.
2. Klabunde, RE. Cardiovascular Physiology Concepts. Lippincott Williams & Wilkins/Baltimore, 2005 (1st edition) and 2012 (2nd edition). A textbook for medical and allied health science students.
3. Klabunde, RE. Cardiovascular Physiology Concepts, www.cvphysiology.com (1999-2014) and Cardiovascular Pharmacology Concepts, www.cvpharmacology.com (2006-2014).
4. RE Klabunde. Teaching physiology to 21st century medical students. The Physiologist 56:1-4, 2013.
5. SB Bender and RE Klabunde. Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha-1-adrenoceptor-medicated vasoconstriction in type 2 diabetes. Am J Physiol Heart Circ Physiol 293:H2281-2288, 2007.
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