Julia Hum, Ph.D.

Assistant Professor of Physiology
(317) 955-6265
jmhum@marian.edu
Evans Center, room #312A

Biography

julia humJulia Hum, Ph.D., is a Biomedical Science Teaching Fellow at the Marian University School of Osteopathic Medicine. She earned a B.S. in biology from Saint Mary's College, Notre Dame, IN. and a Ph.D. in cellular and integrative physiology from Indiana University School of Medicine. She completed her thesis research under the mentorship of Dr. Fredrick Pavalko in the area of cellular signaling that promotes and inhibits the anabolic response of bone cells to mechanical loading. She then completed her postdoctoral studies investigating phosphate regulation by the hormone Fibroblast growth factor 23 (FGF23) in both common and rare diseases in the medical and molecular genetics laboratory of Dr. Kenneth White at the Indiana University School of Medicine.

During her graduate and postdoctoral training Dr. Hum was awarded fellowships based on both on her teaching skills and research proposals. She was selected as a National Science Foundation (NSF) Teaching Fellow for the GK-12 Urban Educators program, served as a graduate teaching assistant for two years and was an invited teaching assistant for a Woods Hole microscopy workshop. She was awarded the American Society for Bone and Mineral Research's (ASBMR) Young Investigator Award as a graduate student. Dr. Hum was selected as an ASBMR Endocrine Fellow during her postdoctoral training and was awarded a postdoctoral fellowship from the American Heart Association (AHA).

Dr. Hum lives in Indianapolis with her husband and young daughter. Having grown up in the Hoosier state, she's a lifelong basketball fan, serving as a volunteer girls' basketball coach with her husband at Saint Thomas Aquinas School. She enjoys time spent outdoors with her family, cycling and nonfiction novels.

Clinical/Reesearch Interests

Dr. Hum's primary research area is bone biology, her research goals include investigating how osteoblasts and osteocytes communicate in response to mechanical and hormonal signaling.

Highlighted Publications

Hum, J.M., O'Bryan, L.M., Tatiparthi, A., Johnson, R.L., Wilson, J.M., Clinkenbeard, E.L., Cass, T.A., Smith, R.C., White, K.E. Sustained expression of a soluble form of aKlotho prevents aortic calcification and disease phenotypes during chronic hyperphosphatemia (In Press: JASN)

Hum, J.M., Clinkenbeard, E.L., Cass, T.A., Allen, M.R., White, K.E. The Metabolic Bone Disease Associated with the Hyp Mutation is Independent of Osteoblastic HIF1a Expression (In Review)

Clinkenbeard, E.L., Cass, T.A., Hum, J.M., White, K.E. A Murine Model with Conditional FGF23 Deletion J Bone Miner Res 2016 Jun 31: (6): 1247-57

White, K.E., Hum, J.M., Econs, M.J., Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis Curr Osteoporos Rep 2014 Sep 12: (3):252-62

Hum, J.M., Day, R.N., Bidwell, J.P., Wang, Y., Pavalko, F.M. Mechanical loading in osteocytes induces the formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression PLoS ONE 2014 May 19: 9(5): e97942

Hum, J.M., Siegel, A.P., Pavalko, F.M., Day, R.N. Monitoring biosensor activity in living cells with fluorescence lifetime imaging microscopy Int J Mol Sci 2012 Nov 7: 13(11): 14385-400

 

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