Bhupal Bhetwal, Ph.D.
Assistant Professor of Physiology and Biochemistry

(317) 955-6673
Evans Center, Room 316


Bhupal P. Bhetwal, M.Sc., Ph.D. is a teaching fellow of Biochemistry and Molecular Cell Biology at MU-COM. Dr. Bhupal P. Bhetwal earned his Masters of Science in Human Physiology from B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal. After teaching Medical Physiology at BPKIHS for four years, he came to the United States for pursuing Ph.D. He earned his Ph.D. in Cellular & Molecular Pharmacology & Physiology from the University of Nevada School of Medicine (UNSOM), Reno (2007-2012) in Dr. Brian A. Perrino's laboratory. After his Ph.D., Dr. Bhetwal pursued his first post-doctoral research training with Dr. Wei Yan and Dr. Kenton M. Sanders in Reno (2012-2014) and second post-doctoral research training with Dr. Susan J. Gunst at the Indiana University School of Medicine, Indianapolis (2014-2016).

Dr. Bhupal Bhetwal's research interests are in smooth muscle contractility and intracellular signaling. Smooth muscles line the inner walls of many hollow organs such as gastrointestinal tract, reproductive tract, airways, uterus, blood vessels, urinary bladder etc. Hence signaling pathways that regulate smooth muscle tone in these organs are of clinical interests. Dr. Bhetwal's master's degree dissertation focused on cardiovascular fitness changes due to physical activity and high altitude adaptation and his doctoral dissertation focused on studying role of Ca2+ sensitization pathways in regulating gastrointestinal smooth muscle contractility in health and chronic diabetes. At MU-COM, Dr. Bhetwal is setting up to extend his research in studying intracellular signaling pathways in various tissues/organs between healthy and obese-diabetic animals and correlate signaling changes with functional changes in tissues/organs. He collaborates with the faculties at the Indiana University School of Medicine, Indianapolis and with biomedical science faculties at the MU-COM for his ongoing research projects.

Dr. Bhetwal enjoys teaching students with clinical applications of the Biochemical/Physiological concepts. He is a member of the American Physiological Society, American Neurogastroenterology and Motility Society, and American Society for Pharmacology and Experimental Therapeutics.

Clinical/Research Interests

Primary research goal: Study intracellular signaling pathways with a focus on roles of protein kinases/phosphatases on smooth muscle contractility in health and disease.

Representative Publications

Changlong An, Bhupal P Bhetwal, Kenton M Sanders, Avril V Somlyo, and Brian A Perrino. Role of telokin in regulating murine gastric fundus smooth muscle tension. PLoS One. 2015 Aug 10;10(8).

Shuiqiao Yuan, Clifford J Stratton, Jianqiang Bao, Huili Zheng, Bhupal P Bhetwal, Ryuzo Yanagimachi, and Wei Yan. Spata6 is required for normal assembly of the sperm connecting piece and tight head–tail conjunction. Proceedings of National Academy of Sciences, USA. 2015 Feb 3; 112(5): E430–E439.

Bhupal P Bhetwal, Changlong An, Salah A Baker, Kristin L Lyon, and Brian A Perrino. Impaired contractile responses and altered expression and phosphorylation of Ca2+ sensitization proteins in gastric antrum smooth muscles from ob/ob mice. Journal of Muscle Research and Cell Motility. 2013 May; 34(2):137-49.

Bhupal P Bhetwal, Kenton M Sanders, Changlong An, Danielle M. Trappenese, Robert S Moreland, and Brian A Perrino. Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus. Journal of Physiology, 2013 Jun 15; 591 (Pt 12):2971-86.Editor's choice and commented.

Bhupal P Bhetwal, Changlong An, Steve A Fisher and Brian A Perrino. Regulation of basal LC20 phosphorylation by MYPT1 and CPI-17 in murine gastric antrum, gastric fundus, and proximal colon smooth muscles. Neurogastroenterology and Motility (Oct, 2011) 23, e425–e436.


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