Karla Kinkade, Ph.D.
Assistant Professor of Biology and Public Health

Biography

Karla Kinkade, Ph.D., Assistant Professor of Biology and Public Health, earned her Ph.D. in Microbiology and Immunology at Indiana University School of Medicine.  She continued her study as a post-doctoral research scientist at the Herman B Wells Center of Pediatric Research at IUSM studying the structure and function of the phagocyte NADPH-oxidase flavocytochrome b558.  She is also certified as a Medical Technologist by the American Society of Clinical Pathologists.  Outside of the biology laboratory, Dr. Kinkade is interested in best practices in teaching and learning.

Education

• Ph.D., Microbiology and Immunology, Indiana University School of Medicine, 1997
• B.A., Chemistry, Hanover College, 1985 

Courses

• BIO 151 General Biology
• BIO 225 Human Anatomy Lab
• BIO 226 General Human Physiology Lab
• BIO 345 Immunology
• PBH 301 Introduction to Epidemiology

Research interests / portfolio

• Analysis of the structure and function of the NADPH-oxidase enzyme
• Immune response to infectious disease
• Integration of faith and science in higher education

Publications

• Biberstine-Kinkade, K.J., Yu, L., Stull, N., LeRoy, B., Bennett, S., Cross, A., and Dinauer, M.C. (2002) Mutagenesis of p22phox Histidine 94: A histidine in this position is not required for flavocytchrome b558 function.  J. Biol. Chem. 277:30368-74.
• Biberstine-Kinkade, K.J., DeLeo, F.R., Epstein, R.I., LeRoy, B.A., Nauseef, W.M., and Dinauer, M.C. (2001) Heme-ligating histidines in flavocytochrome b558: identification of specific histidines in gp91phox. J. Biol. Chem. 276:31105-12.
• Biberstine-Kinkade, K.J., Yu, L., and Dinauer, M.C. (1999) Mutagenesis of an arginine- and lysine-rich domain in the gp91phox subunit of the phagocyte NADPH-oxidase flavocytochrome b558. J. Biol. Chem. 274:10451-7.
• Yu, L., DeLeo, F.R., Biberstine-Kinkade, K.J., Renee, J., Nauseef, W.M., and Dinauer, M.C. (1999) Biosynthesis of flavocytochrome b588: gp91phox is synthesized as a 65 kDa precursor (p65) in the endoplasmic reticulum. J. Biol. Chem. 274:4364-9.
• Biberstine, K.J., Darr, D.S., and Rosenthal, R.S. (1996) Tolerance to appetite suppression induced by peptidoglycan.  Infection and Immunity 64:3641-5.
• Biberstine, K.J., and Rosenthal, R.S. (1994) Peptidoglycan fragments decrease food intake and body weight gain in rats.  Infection and Immunity 62:3276-81.